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AI Systems

Bridging AI and real-world challenges to drive efficiency and opportunity 

A portrait of Tobechukwu Nwabueze {head}University of Tennessee.
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A graduate students installs LiDAR on a robot dog.

UT researchers in AI systems form the bridge between the fundamentals of AI—such as the computing architectures, statistical models, and algorithms that undergird machine learning—and positive outcomes for science, industry, and humanity.

Faculty design and build intelligent systems by coordinating the interactions between distinct AI elements such as machine learning pipelines, autonomous agents, edge AI, and AI-driven simulations. Researchers continue to optimize these systems for accuracy, efficiency, flexibility, and scalability, allowing them to transform workflows, enable process efficiency, and shape decision-making in applications from astronomy to zoology.

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UT’s Approach

UT researchers are integrating AI, machine learning, high-performance computing, and cloud platforms to tackle challenges in large-scale data distribution, storage, and computation, making AI workflows faster, more efficient, and more trustworthy. They are advancing autonomous systems across domains—from globally connected microscopy networks to air mobility to autonomous driving models that improve safety and reduce congestion. In agriculture, faculty combine computer vision, Internet of Things devices, and deep learning to strengthen food security with farm-specific digital twins, robotic pest monitoring, and automated pollination systems. In health and human services, they are developing socially assistive robots for dementia care, AI-enabled surgical systems, and diagnostic tools for conditions like atrial fibrillation. By uniting machine learning frameworks, physical mechanisms, and control systems, UT is creating intelligent robots capable of operating in unstructured environments, expanding the reach of AI into discovery, mobility, agriculture, and health care.

UT has moved quickly and early in the emerging high-potential field of fully automated materials synthesis. The university has invested in our work building AI-enabled systems and workflows. With these unique operational capabilities, UT can truly make an impact on the state, country, and world.”

Sergei Kalinin, Weston Fulton Professor of Materials Science and Engineering, UT; Chief Scientist, AI/ML for Physical Sciences, Pacific Northwest National Laboratory

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Students work in the Grid Visualization Lab at the University of Tennessee, Knoxville.
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Assistant Professor Catherine Schuman speaks to graduate students at the University of Tennessee.

Highlights

AI microscope  at the University of Tennessee, Knoxville.

Kalinin’s AI Microscopist Accelerates Nanoscale Material Characterization

With support from the US Department of Energy, Sergei Kalinin’s team launched a new AI-enabled workflow integrating machine learning, high-performance computing, and advanced microscopy. The workflow can gather useful data up to 100 times faster than conventional methods. 

Learn more about this research.

A surgical robot that is part of a Advanced Research Projects Agency for Health project.

Surgical Robot Project Receives Up to $12 Million in ARPA-H Funding

Caleb Rucker is co-principal investigator in a multi-institutional project to create a surgical robot capable of performing an entire surgery without human intervention. Rucker is leading a UT team in developing computational models to inform the automated surgery system. 

Learn about this landmark project.

Zhenbo Wang, University of Tennessee, Knoxville Associate Professor.

Wang Investigates Autonomous Vehicle Control for Advanced Air Mobility Systems

Zhenbo Wang’s lab is developing and testing a novel airway system coupled with adaptive operational rules and control schemes. They are devising algorithms to facilitate autonomous control, adaptability, and optimal decision-making based on real-time factors.  

Learn about Wang’s vision for air mobility systems.

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Group Combines High Performance Computing and AI to Advance Data Sciences

With a multiple-year award from the National Science Foundation, Michela Taufer is leading research to make developing tailored neural networks faster and more efficient. Improving neural networks in these ways will drive greater efficiency in diverse AI systems with data-based decision-making at their core.

Learn more about this research.

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Facilities & Initiatives

Faculty study and build AI systems in state-of-the-art facilities on and off campus. Centers and research groups receive support from and partner with organizations including the National Science Foundation, the US Department of Energy, the US Department of Transportation, and industry leaders.  

  • Center for Materials Processing 
  • Center for Nanophase Materials Sciences at Oak Ridge National Laboratory 
  • Infrastructure for Scientific Applications and Advanced Computing (ISAAC) 
  • Institute for Advanced Materials and Manufacturing  
  • Materials Research Science Center, Center for Advanced Materials and Manufacturing 
  • Oak Ridge Leadership Computing Facility 
Mahshid Ahmadi works with students inside her lab at the University of Tennessee, Knoxville.

Researchers

  • Rigoberto Advincula

    Associate Professor, Chemical and Biomolecular Engineering

    Computation, simulation, theory, cell biology, immunology, intracellular transport, synthetic biology, systems biology, biomembrane, cytoskeleton, nanoparticle, biophysics, machine learning

  • Sergei Kalinin

    Professor, Materials Science and Engineering

    Physics-based machine learning, autonomous research, single-atom fabrication, scanning probe microscopy, scanning transmission electron microscopy

  • Fei Liu

    Fei Liu

    Assistant Professor, Electrical Engineering and Computer Science

    Computational modeling, advanced control and AI, integrated real-time robotics system

  • Yilu Liu.

    Yilu Liu

    UT–ORNL Governor’s Chair for Power Electronics

    Power systems, smart grid, micro grid, infrastructure reliance, energy policy

  • Sai Swaminathan

    Sai Swaminathan

    Assistant Professor, Electrical Engineering and Computer Science

    Human-computer interaction, accessibility, ubiquitous computing, cyber-physical systems, human-robot interaction.

  • Michela Taufer

    Michela Taufer

    Professor, Mechanical, Aerospace and Biomedical Engineering

    High-performance computing, cloud computing, edge computing, reproducibility, AI-inspired workflows, AI-inspired data analytics 

  • Zhenbo Wang.

    Zhenbo Wang

    Assistant Professor, Mechanical, Aerospace & Biomedical Engineering

    Optimal control; convex optimization; machine learning, guidance, navigation, and control space systems; aerial vehicles; connected vehicles

  • Peng Zhao.

    Peng Zhao

    Associate Professor, Mechanical, Aerospace & Biomedical Engineering

    Battery safety, thermal management, low carbon fuels, advanced combustion strategy, engine-fuel interaction

See all ai systems Faculty

AI Tennessee

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Research Areas

AI for Education and Workforce Development
AI for Knowledge and Discovery
AI Systems
Applied AI
Fundamentals of AI

Research Gateways

UT Research supports five Gateways defining the university’s strategic priorities—AI Tennessee is one of them. Find out about the other four gateways here.

The university is recruiting top-tier faculty members to join two cluster hires, one in Foundational Artificial Intelligence and one in Science-Informed Artificial Intelligence.
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