Donald M. Engelman, Higgins Professor of Biochemistry at Yale University, will present “Insertion of a transmembrane helix, and its uses in targeting tumors” at the Cancer Community of Scholars Symposium Wednesday, March 4. Engelman is a fellow of the American Academy of Arts and Sciences, a fellow of the National Institutes of Health, and has been a Guggenheim fellow.
pHLIPs (pH (Low) Insertion Peptides) are water-soluble peptides that are triggered by low pH to fold and insert one end across a cell membrane. Because a pHLIP is unfolded on the surface of a bilayer and folding is pH-triggered, we are able to begin to observe and understand the molecular events that accompany the insertion and folding of a peptide entering or leaving a bilayer, and I will discuss several of our findings.
The triggered insertion allows pHLIPs to target cells in acidic tissues in vivo, enabling delivery of imaging and therapeutic agents. We have shown targeting of dyes, radioisotopes, nanogold and Peptide Nucleic Acids (PNAs) to tumors in mice, and will report on the use of PNAs to target the suppression of onco-micro RNAs, resulting in tumor growth inhibition in vivo.
Hosted by the Cancer Community of Scholars, UT Medical Center / UT Graduate School of Medicine, UTK Office of Research & Engagement, departments of Biochemistry & Cellular & Molecular Biology and Microbiology
When: Wednesday, March 4, 2015 at 5 p.m.
Where: Wood Auditorium, UT Medical Center
Additional Information: Free and open to the public. Reception following.